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News & Press: Breaking News

First-in-class Nasal Spray Demonstrates Promise for Migraine Pain Relief

Thursday, November 06, 2014   (0 Comments)
Posted by: Dagmar Anderson
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Researchers are developing a novel prochlorperazine nasal spray formulation as a potential new treatment for migraines. This work was presented at the 2014 American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition, the world's largest pharmaceutical sciences meeting, in San Diego, Nov. 2-6.

Migraines are manifested by severe pain and headache that can last anywhere from four to seventy-two hours, accompanied by nausea, vomiting, and sensitivity to both light and sound. Of the 100 million people who experience headaches in the United States, 37 million of them suffer from migraines. According to the Migraine Research Foundation, migraine ranks in the top 20 of the world's most disabling medical diseases, with someone in the United States going to the emergency room every 10 seconds for treatment.

Venkata Yellepeddi, PhD, along with his colleagues from Roseman University of Health Sciences, developed a preservative-free device-driven prochlorperazine nasal spray that could prove useful for compounding pharmacists specifically in the field of pain medicine. "Prochloperazine is a dopamine receptor antagonist that is widely used as an anti-nausea medication. Comparative clinical studies have shown that prochloperazine provides better pain relief than other anti-migraine drugs such as sumatriptan, metoclopramide, and ketorolac," said Yellepeddi. "Currently, there are no marketed nasal spray formulations of prochlorperazine available for the treatment of migraine.


IACP Foundation Grant Funded this Effort

This work was supported by a research grant from International Academy of Compounding Pharmacists (IACP) Foundation. For more information about the IACP Foundation, please click here.


Please click here to read the press release.

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